Endocrine Abstracts

Introduction: Ghrelin is known to strongly stimulate growth hormone release from the pituitary. It was also found to be produced locally in hypothalamus and anterior pituitary and in different types of pituitary adenomas. It’s been suggested that ghrelin synthesized locally in hypothalamo–pituitary area or within pituitary tumours can be an important factor contributing to pituitary tumorogenesis.Aim: The aim of the study was the immunohistoche...

In this study, we attempted to demonstrate the expression of GHSR-1a receptor and possible effects of its activation in human, rat and boar spermatozoa. For demonstration of GHSR-1a immunocytochemical, immunofluorescence and western blotting techniques were applied. The effects of receptor activation was tested in a series of in vitro incubations of spermatozoa with or without addition of ghrelin and the effects were evaluated using confocal microscopy and flow cytometr...

Purpose: Acromegaly is a disease characterized by the excessive secretion of GH. Clinically, it is manifested by overgrowth of tissues and internal organs, which leads to characteristic phenotype. Patients with active acromegaly usually have impaired glucose metabolism. It significantly improves after achieving remission of the disease. Adversely, disturbances in lipid profile are not altering. Moreover, these parameters are even worse in successfully treated patients. Ghrelin...